Carlow man Ed Byrne has been named on the bench for Ireland V Wales in the opening game of the Guinness Series in the Autumn Nations Cup.
There are two uncapped players in the match day 23, James Lowe will make his Ireland debut in an exciting back three that also includes Jacob Stockdale and Hugo Keenan.
Captain Johnny Sexton links up with provincial partner Jamison Gibson Park, who makes his first start after two caps off the bench, in the half-backs.
Robbie Henshaw switches to inside centre with Chris Farrell coming in at 13.
In the pack Cian Healy and Andrew Porter are joined by Ronan Kelleher at hooker. Iain Henderson returns to the second row to partner James Ryan. The backrow sees Caelan Doris switch to No.8 with Peter O’Mahony, winning his 70th cap, at 6 and Josh van der Flier at 7.
The uncapped Billy Burns will be aiming for his first cap as he named in the replacements alongside Conor Murray and the returning Keith Earls.
The replacement forwards are Dave Heffernan, Ed Byrne, Finlay Bealham, Quinn Roux and Will Connors.
15. Jacob Stockdale (Ulster/Lurgan) 30 caps
14. Hugo Keenan (Leinster/UCD) 2 caps
13. Chris Farrell (Munster/Young Munster) 10 caps
12. Robbie Henshaw (Leinster/Buccaneers) 45 caps
11. James Lowe (Leinster) uncapped
10. Jonathan Sexton (Leinster/St Mary’s College) 93 caps CAPTAIN
9. Jamison Gibson Park (Leinster) 2 caps
1. Cian Healy (Leinster/Clontarf) 100 caps
2. Ronan Kelleher (Leinster/Lansdowne) 3 caps
3. Andrew Porter (Leinster/UCD) 28 caps
4. Iain Henderson (Ulster/Academy) 55 caps
5. James Ryan (Leinster/UCD) 28 caps
6. Peter O’Mahony (Munster/Cork Constitution) 69 caps
7. Josh van der Flier (Leinster/UCD) 26 caps
8. Caelan Doris (Leinster/St Mary’s College) 4 caps
16. Dave Heffernan (Connacht/Buccaneers) 3 caps
17. Ed Byrne (Leinster/UCD) 2 caps
18. Finlay Bealham (Connacht/Buccaneers) 11 caps
19. Quinn Roux (Connacht/Galwegians) 12 caps
20. Will Connors (Leinster/UCD) 2 caps
21. Conor Murray (Munster/Garryowen) 83 caps
22. Billy Burns (UIster) uncapped
23. Keith Earls (Munster/Young Munster) 84 caps